From left, Himanshu Arora, Ph.D., with Ranjith Ramasamy, M.D.

Sylvester Researchers Show Nitric Oxide Suppresses Drug-Resistant Prostate Cancer


Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown in animal models that S-nitrosoglutathione (GSNO), a compound that increases nitric oxide (NO) levels, suppresses castration-resistant prostate cancer and has a major impact on tumor microenvironments. The discovery could lead to new therapies for prostate cancer patients with few options.

Carmen Calfa, M.D., right, talks to TAPUR Study participant Anita Shangvi and her daughter.

Sylvester is Sole Florida Site for TAPUR Study


TAPUR — Targeted Agent and Profiling Utilization Registry — is for patients with advanced solid tumors in a variety of cancers, including breast, ovarian, pancreatic, and head and neck, which are no longer responding to standard cancer treatments.

Sylvester Comprehensive Cancer Center.

Florida Cancer Data System at Sylvester is Again Recognized as One of the Best in the U.S.


The Florida Cancer Data System, the State of Florida’s legislatively mandated population-based registry located at Sylvester Comprehensive Cancer Center, has received three important distinctions for the quality of its cancer registry data. For the 16th consecutive year, the Florida Cancer Data System (FCDS) has received Gold Certification from the North American Association of Central Cancer Registries.

Sylvester Researchers Focus on an Interesting Target: PRMT5


Cancer researchers spend a lot of time looking for good targets: potentially druggable molecules (mostly proteins) that affect cancer progression. The laboratory of Stephen D. Nimer, M.D., director of Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, has spent the past decade investigating an enzyme called PRMT5, which plays a role in leukemia, lymphoma and other cancers.

Sylvester Researchers Discover A Novel Mediator of Genome Instability Relevant to Many Cancers


A research team at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine has discovered a novel role for a protein factor that allows it to contribute to the genome instability observed in many cancer cells. The investigators found that the FANCA protein plays an unexpected role in an error-prone DNA repair pathway that can drive the common instability mechanism.

CTSI Leadership and Central Operations Team: from left, top row, Patricia Avissar, Caprice Battle, Marisabel Davalos, Jonelle Wright, Ph.D., Sheela Dominguez and Stella Covelli; from left, bottom row, Rosalina Das, Raquel Perez, Dushyantha Jayaweera, M.D., Ralph L. Sacco, M.D., M.S., Daru Lane Ransford and Chin Chin Lee.

Major NIH Award Makes Miami CTSI a Hub for Biomedical Discovery and Innovation


The Miami Clinical and Translational Science Institute has received a five-year $21.5 million National Institutes of Health grant, which will be supplemented by the Miller School of Medicine and the University of Miami Office of the Provost, to fund collaborative research to speed the discovery of new medical treatments and cures.

A photographic image showing a retinoblastoma.

Researchers Receive Grant to Study Retinoblastoma in Children


J. William Harbour, M.D., and Daniel Pelaez, M.D., researchers at Sylvester Comprehensive Cancer Center and Bascom Palmer Eye Institute at the University of Miami Miller School of Medicine, have been awarded a $250,000 grant by Alex’s Lemonade Stand Foundation for their 2018 Innovation Grant application titled “Molecular Landscape for Targeted Therapy in Retinoblastoma.”

Study collaborators, from left: Haley Perlow, Miller School medical student; Laura Huang M.D., physical medicine and rehabilitation specialist; Stuart Samuels, M.D., Ph.D., principal investigator; Diana Molinares, M.D., physical medicine and rehabilitation resident; and Gregory Azzam, M.D., Ph.D., radiation oncology resident.

Sylvester Researcher Receives Grant to Study Long-Term Side Effects of Head and Neck Radiotherapy


Radiation therapy can be an effective treatment for people diagnosed with head and neck cancer. However, weeks, months or years after treatment, a debilitating side effect — fibrosis of the skin, subcutaneous tissue and muscles of the neck — often arises. This excess production of fibrous connective tissue and scarring can significantly decrease patient quality of life and limit physical function.

Doyoung Chang, Ph.D., in his laboratory.

Robotics Lab Opens for Business


Not long ago, Doyoung Chang, Ph.D., was designing robots that may be climbing — and cleaning — the walls of skyscrapers one day. Now the biomechanical engineer is intent on perfecting a robotic arm that helps cancer fighters at Sylvester Comprehensive Cancer Center and across the University of Miami Health System obliterate small tumors with a heat-delivering needle inserted through the skin.