Dr. Stephen D. Nimer in the lab.

Sylvester Research Identifies Novel Vulnerability in Acute Leukemia Cells


Researchers at the NCI-designated Sylvester Comprehensive Cancer Center, working within several departments at the University of Miami Miller School of Medicine, have identified another critical component of the AML1-ETO multi-protein complex that could point the way to more effective therapies for acute myeloid leukemia (AML).

Sylvester Researchers Find PARP Inhibitors Could Be a New Treatment for a Common Lymphoma


A study looking at PARP inhibition in diffuse large B cell lymphoma opens the door to a new way to treat this common type of cancer, according to study author Izidore S. Lossos, M.D., endowed director of the Lymphoma Program at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and head of the Hematological Malignancies Site Disease Group.

A pathology slide of alveolar soft-part sarcoma.

A Paradigm Shift for Hard-to-Treat Sarcomas


Two recent studies by Sylvester Comprehensive Cancer Center researchers are the first to suggest that immunotherapy plays a key role in treating sarcomas, namely angiosarcoma and alveolar soft-part sarcoma. The findings could change the treatment paradigm for sarcoma types that have few if any treatment options.

Graduate student Marie E. Maloof, left, with Dr.  Nagi Ayad

Researcher Identifies Potential Target for Treating Aggressive Brain Tumors in Children


A researcher at Sylvester Comprehensive Cancer Center of the University of Miami Miller School of Medicine has identified a potential target for halting the unchecked cell division in medulloblastoma, the most common pediatric brain tumor. However, laboratory studies indicate that inhibiting cellular division must be done carefully during a relatively narrow window of time to avoid damage to a child’s still-developing brain.

From left, Alfred Sanchez, president of the Greater Miami Chamber of Commerce, Dr. Stephen D. Nimer, and Felipe F. Basulto, chair of the Greater Miami Chamber.

Sylvester Receives Trailblazer Award from Miami Chamber


The Mary Brickell Trailblazer Award, named after one of Miami’s founders, is given by the Greater Miami Chamber of Commerce to those at the forefront of achieving something significant, a leader in their field. On August 7 that award was presented to Director Stephen D. Nimer, M.D., on behalf of Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine.

From left, Sabita Roy, Ph.D., with first author Li Zhang, M.S.

Researchers Find Probiotics Can Reduce Morphine Tolerance in Mice


A group of researchers from Sylvester Comprehensive Cancer Center, the Department of Surgery and the Department of Medicine at the University of Miami Miller School of Medicine have found that probiotics can reduce morphine tolerance when used as an adjunct therapy in germ-free mice.