The Florida Cancer Data System, the State of Florida’s legislatively mandated population-based registry located at Sylvester Comprehensive Cancer Center, has received three important distinctions for the quality of its cancer registry data. For the 16th consecutive year, the Florida Cancer Data System (FCDS) has received Gold Certification from the North American Association of Central Cancer Registries.
Cancer researchers spend a lot of time looking for good targets: potentially druggable molecules (mostly proteins) that affect cancer progression. The laboratory of Stephen D. Nimer, M.D., director of Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, has spent the past decade investigating an enzyme called PRMT5, which plays a role in leukemia, lymphoma and other cancers.
A research team at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine has discovered a novel role for a protein factor that allows it to contribute to the genome instability observed in many cancer cells. The investigators found that the FANCA protein plays an unexpected role in an error-prone DNA repair pathway that can drive the common instability mechanism.
The Miami Clinical and Translational Science Institute has received a five-year $21.5 million National Institutes of Health grant, which will be supplemented by the Miller School of Medicine and the University of Miami Office of the Provost, to fund collaborative research to speed the discovery of new medical treatments and cures.
J. William Harbour, M.D., and Daniel Pelaez, M.D., researchers at Sylvester Comprehensive Cancer Center and Bascom Palmer Eye Institute at the University of Miami Miller School of Medicine, have been awarded a $250,000 grant by Alex’s Lemonade Stand Foundation for their 2018 Innovation Grant application titled “Molecular Landscape for Targeted Therapy in Retinoblastoma.”
Radiation therapy can be an effective treatment for people diagnosed with head and neck cancer. However, weeks, months or years after treatment, a debilitating side effect — fibrosis of the skin, subcutaneous tissue and muscles of the neck — often arises. This excess production of fibrous connective tissue and scarring can significantly decrease patient quality of life and limit physical function.
Not long ago, Doyoung Chang, Ph.D., was designing robots that may be climbing — and cleaning — the walls of skyscrapers one day. Now the biomechanical engineer is intent on perfecting a robotic arm that helps cancer fighters at Sylvester Comprehensive Cancer Center and across the University of Miami Health System obliterate small tumors with a heat-delivering needle inserted through the skin.
A Sylvester Comprehensive Cancer Center viral oncology researcher has discovered a key cellular pathway associated with activating Kaposi sarcoma, a rare cancer most often found in people with HIV/AIDS or otherwise compromised immune systems. “We have identified the main oncogenic driver of the tumor and the viral mechanism of activation,” said lead author Enrique A. Mesri, Ph.D.
Sarcoma specialist Jonathan Trent, M.D., Ph.D., and his team, including Breelyn Wilky, M.D., received the first GIST Center of Excellence award on behalf of Sylvester Comprehensive Cancer Center from The Life Raft Group on July 14 during Life Fest 2018, a weekend conference for patients, caregivers and medical experts.
Expanding on previous work highlighting disparities in cancer risk and mortality among diverse populations in Florida, a research team from Sylvester Comprehensive Cancer Center analyzed almost 250,000 people who died from cancer between 2008 and 2014 in another state with a diverse population: New York. Results of this new study were published on July 19 in the journal Cancer Epidemiology, Biomarkers & Prevention.